Hakim Bangun
University of Sumatera Utara,Indonesia.
Title: Floating gastroretentive drug delivery system of antacids nanoparticles using hard alginate capsules.
Biography
Biography: Hakim Bangun
Abstract
The conventional antacids dosage forms have short duration of action due to the gastric emptying process. Since the healing of gastric ulcers occurs when gastric pH is kept above 3-4, so a gastroretentive dosage form of antacids with prolonged its duration of action is needed to produced to faster the heal of gastric ulcers. The purose of this study is prolong the duration action of antacids by preparation floating gastroretentive drug delivery system of antacids using hard alginate capsules. Hard alginate capsules were prepared in our laboratory by using sodium alginate. Then, alginate capsules perforated which 1 hole in body part and 1 hole in cup part, the diameter of hole was 1 mm. Conventional antacids powder were grinded by using Planetory Micro Mill Premium Line (Frittsch) to form antacids nanoparticles. The size of Mg(OH)2 nanoparticles was 186-372 nm and Al(OH)3 was 186-223 nm. Mg(OH)2 and Al(OH)3 nanoparticles were filled into separated alginate capsule, 200 mg each capsule. Buffering action of antacids to 0.1 N HCl solution was determined on simulated gastric acid secretion. The healing effects of antacids nanoparticles on gastric ulcers was tested using male rats induced by 0.6 N HCl solution. Examinations of gastric ulcers were observed macroscopically (number of lesions and lesion index) and microscopically (histopathology). The results of this study showed that during the experiment for about 12 hours alginate capsules were floated and did not disintegrate in the 0.1 N HCl solution, it disintegrated in simulated intestinal fluid. Floating gastroretentive drug delivery system of antacids nanoparticles using perforated hard alginate had buffering action. In simulated gastric fluid secretion experiment, the capsules containing antacid caused the pH raised above 1.2 and maintained the pH of solution at 3.6 for 12 hours. While, perforated alginate capsule containing conventional antacids powder, the pH of medium reached only to 1.3 for 12 hours. On the capsules without perforation containing antacid nanoparticles the pH of medium was almost no changed at pH 1.2-1.3 for 12 hours. The holes of alginate capsules and the nanosize of antacids caused the easily reaction between HCl and antacids and neutralized the solution. The healing effect of antacids nanoparticles on gastric ulcers was faster then that of conventional antacids. It is concluded that hard alginate capsules is potential to be used as new gastroretentive drug delivery system of antacids.