Vamshi Krishna Tippavajhala
Manipal University,India.
Title: Formulation, optimization and evaluation of valsartan nanostructured lipid carriers.
Biography
Biography: Vamshi Krishna Tippavajhala
Abstract
The present study focuses on the formulation, optimization and evaluation of valsartan nanostructured lipid carriers (NLCs) to improve the oral bioavailability of valsartan. The valsartan NLCs were prepared by ultrasonication emulsification technique and optimised using 23 full factorial design. Glyceryl monostearate and castor oil were used as solid lipid and liquid lipid respectively. A combination of Tween-20 and sodium lauryl sulphate was used as surfactant mixture. The optimized formulations were evaluated for their average particle size, polydispersity index (PDI), zeta potential (ζ), entrapment efficiency, in vitro drug release and in vivo pharmacokinetic parameters like Cmax, Tmax, AUC, apparent volume of distribution, elimination half-life, elimination rate constant and clearance. The optimized valsartan NLCs had an average particle size of 150.0±2.65 nm, PDI of 0.278±0.0065, zeta potential of -46.1±3.24 mV and an entrapment efficiency of 32 %. In vitro drug release studies exhibited a good correlation with in vivo pharmacokinetic studies. In vivo pharmacokinetic data of valsartan NLCs in comparison to pure valsartan dispersion showed a 1.72-fold increase in the bioavailability when administered orally to male Wistar rats. These obtained results clearly indicate an enhancement in the oral bioavailability of valsartan which may help to modify the dosage regimen of valsartan.