Biography
Biography: Anjana Pandey
Abstract
Nanoparticle technology has recently shown to hold great promise for drug delivery applications and as suitable nanomedicine due to its favourable properties such as bioavailability, lower toxic effects and targeted delivery. Regardless of the great progress in nanomedicine, there remains many limitations prior to widely being accepted for medical application. The size of the nanoparticles ranges from 10 to 200 nm, about the size of a protein. Because of their small size, nanoparticles can readily interact with biomolecules on the cell surface or inside cell allowing these nanoparticles to penetrate tissues in depths with a high level of specificity.
Titanium dioxide nanoparticles (Titania) are having least toxicity to normal cell in comparison to cancerous cell lines studied in HT29 (colorectal cancer cell line) and T4056 (normal cell line). These nanoparticles are synthesized by sol-gel method in the presence of surface active agent and characterized by xrd, TEM and photoluminescence. The antioxidant activity of these nanoparticles are also tested by standard DPPH method. These results also corroborated our findings of cytotoxicity substantiated with fluorescence microscopy.