Chen-Sheng Yeh
National Cheng-Kung University, Taiwan
Title: Stimuli-responsive nanomaterial’s in cancer therapy
Biography
Biography: Chen-Sheng Yeh
Abstract
The use of state-of-the-art noninvasive therapies at the organ level in modern medicine has gradually become possible. However, cancer treatment demands for spatially and temporally controlled noninvasive therapy at the cell level because nonspecific toxicity often causes complicated side effects. To increase survival in cancer patients further, combination therapy and combination drugs are explored which demand for high specificity to avoid combined drug side effects. The high specificity could be obtained by implementing stimuli-responsive nanoparticles in photo- and ultrasound-induced therapy. To refine this therapy and subsequently achieve high efficiency, novel nanomaterials can be designed and modified either to enhance the uptake and drug delivery to the cancer site, or control treatment to administer therapy efficiently. These modifications and developments have been demonstrated to achieve spatial and temporal control when conducting an in vivo xenograft. The nanoplatforms discussed in this talk include core-shell Fe3O4@Au nanotrisoctahedra, rattle-type Fe3O4@CuS nanoparticle, and H2O2/Fe3O4-PLGA polymersome.
